Structural shifts in a tiny channel protein help microbes pump out life saving antibiotics. Deep inside bacterial membranes, TolC acts as a molecular escape hatch, helping Gram negative bacteria expel compounds including β lactam antibiotics.
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Proteins flex, breathe, and communicate. Multiply Perturbed Response finds small cooperative sets of residues that efficiently drive a protein from apo to holo, pointing to practical insertion neighborhoods for biosensors.
Read MoreInstead of switching drugs and hoping for the best, we can plan sequences that steer evolution backward, nudging microbes toward genotypes that are vulnerable again, using genotype graphs and drug specific transition maps.
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